ࡱ>   !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstvwxyz{|}~RdO)v({PowerPoint Document(SummaryInformation(@DocumentSummaryInformation8\(( / 00DTimes New RomanPsXs&DVerdanaw RomanPsXs&" DMonotype SortsPsXs&0DSymbole SortsPsXs& ` .  @n?" dd@  @@``   p m)4          4      ()#$%&'" !c $ wwwn*W@8b g4FdFdsH7/m pnpB <4BdBd`gʚ;g4BdBdsH7/Xp@ pp<4!d!d`gʚ;uʚ;2Nʚ;<4dddd`uʚ;ph___PPT2001D<4X? %O =g    ' ( +NIH Review Criteria ,NIH Review Criteria Significance < www! www www.NIH Review CriteriaSignificance Approach F$0 wwwZ%0 wwwZwww /NIH Review Criteria!Significance Approach Innovation F!$0 wwwZ%0 wwwZ!www 0NIH Review Criteria.Significance Approach Innovation Investigator F.$0 wwwZ%0 wwwZ.www 1Grant Components$The  Other Stuff @ P0Z((3Grant Components*The  Research Plan @ P0Z($;A. Specific Aims <A. Specific AimsMost Important PAGE > www! wwwwww=A. Specific Aims(Most Important PAGE Two Main Components F($0 wwwZ%0 wwwZ(www >A. Specific AimsEMost Important PAGE Two Main Components Body - A Mini Grant Proposal FE$0 wwwZ%0 wwwZEwww ?B. Background & Significance' @B. Background & Significance'Why Spend The Money? > www! wwwwwwAC. Preliminary Data BC. Preliminary DataDemonstrate Your Expertise > www! wwwwwwDD. Research Methods ED. Research Methods Overview > www! www wwwFD. Research Methods#Overview Research Team/Environment F#$0 wwwZ%0 wwwZ#www GD. Research Methods6Overview Research Team/Environment Timeline/Timetable F6$0 wwwZ%0 wwwZ6www HD. 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T Click to edit Master title style! !<  s *`. ` <$< ` RClick to edit Master text styles Second level Third level Fourth level Fifth level!     S  s * . ``  >*D  s *. h   *G. Scott Gazelle, MD, MPH, PhD Institute for Technology Assessment$DC   s *. `   @*T  <޽h? f3f  PULSE&   a&Y& %( (   H2,$@ ,   3 0e0e     ?B)CDElFt @ 5% 8c8c     ?1 0u0@Ty2 NP'p<'p @A)BCD|E?||c $)6N_i> _4% #j +  y  p  d(78@ #  3 0e0e     ?BCnDEF @ 5% 8c8c     ?1 0u0@Ty2 NP'p<'p @A)BCD|E?||//  MoK0YVS_^tT, [v] T5  G r C  ]smm#h g:Y/x|!  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S  6 `P   >*   60 `   @* H  0޽h ? ̙33_  @8(  8 8  `Pm ddXX??A l.Grant Writing, Session 2: From Aims to Methods"/(.,K 8 <^ ??`   G. Scott Gazelle, MD, MPH, PhD Institute for Technology Assessment Massachusetts General Hospital Harvard Medical School Harvard School of Public Health% H 8 0޽h ? f3f_    P4s(  4; 4 0pn/ ,$D , 5Guidelines for Writing a Successful Grant ApplicationV6(K<<<<H 4 0޽h ? f3f   D<p(    0X0P ,$D , b It s like dj vu all over again. Yogi Berra $(K  K$<  H  0޽h ? f3f   /(    0 ,$D , cRead the Directions48_KPPH  0޽h ? f3f     1(      0`_ ,$D , eFollow the Directions48_KPPH   0޽h ? f3f  h  $(  $ $ 0 fl\q ,$D, Significance does the research address an important problem? if successful, how will knowledge be advanced? what will be effect on concepts that drive this field?N (u2}0 K_ $ 0>h $  fb ddXX?    H $ 0޽h ? f3f  h  ((  ( ( s *`b 9<$<   ( 0cl\,$D, oApproach are the conceptual framework, design, methods and analyses adequately developed, well integrated and appropriate to the aims of the project? does the applicant acknowledge potential problem areas and consider alternative approaches?N (u2}0 K_ $ 0>h (  fd ddXX?    H ( 0޽h ? f3fV  h  ,~(  , , s *@d 9<$<   , 0_l\<,$D, >Innovation are the aims original and innovative? are novel concepts, approaches or methods proposed? does the project challenge existing paradigms or develop new methodologies or technologies?N (u2}0 K_ $ 0>h ,  f ` ddXX?    H , 0޽h ? f3fq  h   0(  0 0 s *e 9<$<   0 0hl\ ,$D, YInvestigator is the investigator appropriately trained and well suited to carry out the proposed research? is the proposed research appropriate to the experience level of the principal investigator and co-investigators?N (u2}0 K_ $ 0>h 0  fh ddXX?    H 0 0޽h ? f3f  h  +#4(  4 4 s *@a 9<$<   4 0@gl\,$D, {Environment does the scientific environment in which the work will be done contribute to the probability of success? do the proposed experiments take advantage of unique features of the scientific environment or employ useful collaborative arrangements?N (u2}0 K_ $ 0>h 4  f i ddXX?    H 4 0޽h ? f3f .  ZR8(  8 8  0f 0<$ <   8  ixaxad @1 ? jq`    8 s `Dlxaxad @1 ? p$p<4___PPT9 ^Abstract Budgets and Budget Justification Biosketches Environment/Resources Letters of Support"_ uK2_ ) * 0>H 8 0޽h ? (I[P 0  ZRH(  H H  0Dl 0<$ <   H  @Clxaxad @1 ? jq`    H s Clxaxad @1 ? p$p<4___PPT9 A. Specific Aims B. Background and Significance C. Preliminary Data D. Research Methods E. Human Studies F. Animal Studies" uK#  0>H H 0޽h ? (I[P  h  |th (  h h 0@l\,$D, ~Most Important PAGE  executive summary - tells where research is going remainder of proposal must flow from it MAJOR influence on reviewers and their critiques may be the only page non-assigned reviewers read write it first, last, and every day in betweenN(u2}0 K_$ 0>h h  fB ddXX?    H h 0޽h ? f3f  h   l(  l l s *0C 9<$<  p l 0Cl\f ,$D, ^Two Main Components body - generally 2-4 paragraphs aims - often with corresponding hypothesesN(u2K}0 K_$K 0>h l  fPD ddXX?    H l 0޽h ? f3fV  h  0p~(  p p s *C 9<$<   p 0El\,$D, >Body - A Mini Grant Proposal goal of the proposed research background/medical significance/unresolved problems preliminary data (confidence in PI) general approach deliverables/long term goalsN(u2}0 K_$ 0>h p  fE ddXX?    H p 0޽h ? f3fl  h  @t(  t t s *F 9<$<   t 00Fl\<,$D, TThe Aims Themselves broad, clearly defined aims (generally 3) precise sub-aims: clear statement of work, using strong terms such as define, determine, demonstrate specific hypotheses: best if correspond to the aimsN(u2}0 K_$ 0>h t  fH ddXX?    H t 0޽h ? f3f  h  NFPx(  x x 0Il\<,$D, PWhy Spend The Money? current state of knowledge and unresolved issues demonstrate potential major impact on healthcare does NOT mean that project has to be too large in scope - FOCUS IS GENERALLY VERY IMPORTANTN(u2}0 K_$ 0>h x  fI ddXX?    H x 0޽h ? f3f  h  `|(  | | s *PJ 9<$<   | 0Jl\<,$D, hRelationship to Other Work in Field should be scholarly, objective, well-referenced, BUT this is not a review article or book chapter provide compelling justification for proposed research know the study section & reference their workN$(u2}0 K_$$ 0>h |  f0؜ ddXX?    H | 0޽h ? f3f  h  MEp(    0؜l\G,$D, ODemonstrate Your Expertise as a researcher/P.I. with specific techniques to be used clinical expertise and access to patients highlight expertise of collaborators and demonstrate how they will complement yoursN(u2}0 K_$ 0>h   fpݜ ddXX?    H  0޽h ? f3f|  h   (    s *ݜ 9<$<    00ޜl\<,$D, dData Should Support Aims of Study ideally, preliminary data suggests need for your study indicate to reviewers that specific aims are reasonable, based on current knowledge and prior work note: NIH uses 5% acceptable failure rateN"(u2}0 K_"$ 0>h   f ddXX?    H  0޽h ? f3fp  h  (    0l\q ,$D, Overview summarize work to be done and why it is important often very similar to body/text of aims page overall approach should seem logicalN (u2}0 K_ $ 0>h   fP ddXX?    H  0޽h ? f3fa  h  (    s *p  <$<    0l\<,$D, IResearch Team/Environment convince reviewers you have the best possible team describe roles of key personnel highlight institutional strengths that make it likely the proposed research will be successfulN(u2}0 K_$ 0>h   fl ddXX?    H  0޽h ? f3f  h   (    s *Pl  <$<    00Rl\,$D, pTimeline/Timetable text and graphics justify funding period requested, especially with modeling - they often do not understand time needed detail helps to convince reviewers that you understand the project and have thought through the methodsN(u2}0 K_$ 0>h   fT ddXX?    H  0޽h ? f3f  h  ((    s *S  <$<  |  0Tkl\,$D, jDetailed Methods should parallel the aims and test the hypotheses - put them in VERBATIM (and check to make sure they are!) include patient recruitment strategies, sample size calculations, and statistical or other methods absolutely no  hand waving - if you know you are glossing over something, then fix itN(u2%}0 K_$% 0>h   fW ddXX?    H  0޽h ? f3f  h  H@(    s *W  <$<  ,  0pWvl\,$D, Anticipated Results & Limitations important section that is frequently omitted should anticipate potential problems and propose possible solutions opportunity for dialog with reviewer provides reviewer insight into how you might handle the problems that will almost invariably ariseN"(u2}0 K_"$ 0>h   fpZ ddXX?    H  0޽h ? f3f  h  G?(    0[l ,$D, IPoor Science ultimately, the quality of the proposed research is the most important thing in any grant proposal - sending in an application with poor science is the surest way to failb (u2|8 K_ $ 0HH   f\ ddXX?    H  0޽h ? f3f   h  5(    s *]  <$<    0 Þl& ,$D, uPoor Organization if the proposal is hard to follow, the reviewer will get frustrated and/or angry and give up tryingP(u2d|8 K_$d 0HH   fÞ ddXX?    H  0޽h ? f3f  h  #(    s *Þ  <$<    0Şl ,$D, sPoor Integration the different parts of the proposal must clearly relate to each other - you must convince the reviewer that the work is worth doing (background), can be done (preliminary data), and has been carefully thought through (methods)P(u2|8 K_$ 0HH   fƞ ddXX?    H  0޽h ? f3f,  h  T(    s * ƞ  <$<    0Ǟl ,$D, Contradiction, Superficiality proposal should be internally consistent and detailed enough that the reviewer doesn t have to wonder what you will really do with all the time and money you are asking forP(u2|8 K_$ 0HH   f ɞ ddXX?    H  0޽h ? f3fj  h  0(    s * m  <$<    0m;<,$D, RLack of Qualifications the P.I. (you) should be capable of doing the work collaborators & support personnel should be sufficiently qualified and adequately funded work should be feasibly conducted in environment N(u2}0 K_$ 0>h   fm ddXX?    H  0޽h ? f3f    0(    0@ʞ,$D , dRemember & 4 8_K PPH  0޽h ? f3f  h  :20P(  P P 0ʞ 4 ,$D, ~"Think Like a Reviewer at All Times0#(u2"$hh P  f˞ ddXX?     P 0`˞` VGeneral Guidelines( 2$ H P 0޽h ? f3f  h  ph@T(  T T  f@͞ ddXX?     T 0̞` VGeneral Guidelines( 2$  T <`Ξ  d<$<   T 0p]  ,$D, JTake Pity on the Reviewers proposal should be interesting and easy to readd u200K_$$$0[[H T 0޽h ? f3f  h  PX*(  X X s *0 d<$<   X  f ddXX?     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Specific AimsA. Specific AimsA. Specific AimsA. Specific AimsB. Background & SignificanceB. Background & SignificanceC. Preliminary DataC. Preliminary DataD. Research MethodsD. Research MethodsD. Research MethodsD. Research MethodsD. Research MethodsWhy Grants FailWhy Grants FailWhy Grants FailWhy Grants FailWhy Grants FailPowerPoint PresentationGrantwriting PointersGrantwriting PointersGrantwriting PointersGrantwriting PointersGrantwriting Pointers  Fonts UsedDesign Template Slide Titles$%_ Nancy SperoniCurrent User-RdO)һ({PowerPoint Document(SummaryInformation(@DocumentSummaryInformation8\  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstvwxyz{|}~Current User- Grants FailWhy Grants FailWhy Grants FailWhy Grants FailWhy Grants FailPowerPoint PresentationGrantwriting PointersGrantwriting PointersGrantwriting PointersGrantwriting PointersGrantwriting Pointers  Fonts UsedDesign Template Slide Titles$%_ Nancy Speroni